中国临床药理学与治疗学2009，Vol.14Issue(7)：804-807,4.
五酯胶囊对肾移植受者他克莫司血浓度影响的临床研究
Clinical study for the effects of Wuzhi-capsule on blood concentration of tacrolimus in renal transplant recipients
摘要
Abstract
To study the effects of Wuzhi-capsule (WZ) on the blood concentrations of Tacroli-mus (Tac) in renal transplant recipients. METH-ODS: The renal transplant recipients were divided into experimental group (45 cases) which treated with Tac plus WZ and control group (45 cases) which were re-ceived Tac alone. The blood concentrations of Tac and biochemical values of hepatic and renal functions were determined. RESULTS: The blood concentrations of Tac were significantly higher in experimental group than those in experimental group before combined with WZ( P < 0.01) or in control group ( P < 0.01) . The biochemical values of hepatic and renal functions be-tween experimental group and control group were no significant difference. CONCLUSION: The WZ can markedly elevate the blood concentrations of Tac in re-nal transplant recipients and does not increase the liver and kidney toxicity of Tac at the same time. The treat-ment of WZ combined with Tac can reduce the dosages and costs of Tac in renal transplant recipients.关键词
肾移植/他克莫司/血药浓度/五酯胶囊Key words
renal transplantation / tacrolimus /blood concentration/ Wuzhi-capsule分类
医药卫生引用本文复制引用
李罄,辛华雯,吴笑春,余爱荣,熊磊..五酯胶囊对肾移植受者他克莫司血浓度影响的临床研究[J].中国临床药理学与治疗学,2009,14(7):804-807,4.基金项目
湖北省卫生厅科研基金资助(2007JX3B38) （2007JX3B38）
