中国临床药理学与治疗学2009，Vol.14Issue(7)：823-826,4.
银杏叶提取物对糖尿病肾病抗氧化应激及血液流变作用的影响
Effect of ginkgo leaf extract on oxidative stress and haemodynamics in diabetic nephropathy patients
张丽丽 1刘淑华 1汪福良 1赵志明 1马红梅1
作者信息
- 1. 武汉大学人民医院老年病科,武汉,430060,湖北
- 折叠
摘要
Abstract
To investigate the effect of ginkgo leaf extract on oxidative stress and haemodynamics of diabetic nephropathy ( DN). METHODS: The patients of DN were divided into ginkgo leaf extract treatment group and control group. The changes of serum super-oxide dismutase ( SOD ) , glutathione peroxidase ( GSH-Px) , malondialdehyde ( MDA) and hemorheology in-dexes were observed. RESULTS: Before treatment, serum SOD, GSH-Px, MDA and hemorheology indexes had no significant difference between ginkgo leaf extract treatment group and control group. After treatment, the serum levels of T-SOD and GSH-Px were increased; the level of MDA, hemorheology indexes,erythrocyte aggregation index and platelet aggregation rate were de-creased significantly in ginkgo leaf extract treatment group compared with those in control group ( P < 0.01). CONCLUSION: The antioxidant ability of cells were deceased in DN. Ginkgo leaf extract could protect the renal function by increasing the activities of SOD and GSH-Px, improving the hemorheology, de-creasing the albuminuria.关键词
银杏叶提取物/糖尿病肾病/氧化应激/血液流变学Key words
ginkgo leaf extract/ diabetic ne-phropathy/ oxidative stress/ hemorrheology分类
医药卫生引用本文复制引用
张丽丽,刘淑华,汪福良,赵志明,马红梅..银杏叶提取物对糖尿病肾病抗氧化应激及血液流变作用的影响[J].中国临床药理学与治疗学,2009,14(7):823-826,4.
