吡格列酮二甲双胍片治疗2型糖尿病的多中心随机双盲平行对照临床试验OA北大核心CSCDCSTPCD
Randomized,double-blind,double-dummy,controlled clinical trial of pioglitazone /metformin in the treatment of type 2 diabetes
目的 以盐酸二甲双胍和盐酸吡格列酮(均降糖药)为对照,评价吡格列酮二甲双胍片治疗2型糖尿病的疗效和安全性.方法 用多中心随机双盲双模拟阳性平行对照的试验设计,观察240例2型糖尿病病人,分为吡格列酮二甲双胍片组(试验组)和盐酸二甲双胍、盐酸吡格列酮组(对照组).结果 用药16周后,与基础值相比,试验组空腹血糖(FBG)、餐后2 h血糖(P2hBG)、糖化血红蛋白(HbAlC)分别下降(1.92±1.77)mmol·L~(-1),(2.49±3.1…查看全部>>
Objective To evaluate the efficacy and safety of pioglitazone /metformin hydrochloride in the treatment of type 2 diabetes mellitus patients. Methods A randomized, double-blind, metformin and pioglitazone hydrochloride-controlled, and multicenter clinical trial was conducted. A total of 240 patients with type 2 diabetes mellitus were enrolled in this study, in which 120 patients received pioglitazone/ metformin, and 120 patients received metformin and piogli…查看全部>>
胡红琳;王长江;张木勋;阎胜利;刘俊江;朱旅云;何勇;高雅
安徽医科大学第一附属医院内分泌科,合肥,230022安徽医科大学第一附属医院内分泌科,合肥,230022华中科技大学同济医院内分泌科,武汉,250001青岛大学附属医院内分泌科,青岛,266001河北省人民医院内分泌科,石家庄,050000中国人民解放军白求恩国际和平医院内分泌科,石家庄,050000安徽医科大学第一附属医院内分泌科,合肥,230022安徽医科大学第一附属医院内分泌科,合肥,230022
医药卫生
2型糖尿病吡格列酮二甲双胍片盐酸吡格列酮盐酸二甲双胍
type 2 diabetes mellitus pioglitazone /metformin metform in hydrochloride pioglitazone hydrochloride
《中国临床药理学杂志》 2009 (6)
483-486,4
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