中国临床药理学杂志2009，Vol.25Issue(6)：509-513,5.
丹红注射液对兔离体左心室心电图及致心律失常作用
In vitro effects of Danhong injection on electrocardiogram and proarrhythmias in the rabbit left ventricular wedge preparation
薛小临 1刘腾先 2杨琳 1王东琦 1崔长琮 1严干新2
作者信息
- 1. 西安交通大学医学院第一附属医院心内科,西安,710061
- 2. Main Line Health Heart Center,Wynnewood PA,19096 USA
- 折叠
摘要
Abstract
Objective To investigate the effects of Danhong injection on electrical activity of rabbit heart. Methods The arterially perfused rabbits left ventricular preparations were used in the experiments. The preparations were stimulated at basic cycle lengths (BCL) of 1000 ms for 1 h before the experiment started. The Danhong injection was set in trial group. Captopril was set as a negative control group and sparfloxacin as a positive control group. The transmural ECG was recorded and QRS duration, QT interval, Tp-e interval and Tp-e/QT ratio were measured. Results Donghong injection had no significant effect on QRS duration in the concentration ranges tested. At concentrations of 20 mL · L~(-1) and 60 mL · L~(-1), Danhong injection could produce a small but statistically significant QT prolongation. However, this effect is comparable to the negative control drug captopril. Both Danhong injection and captopril had no significant effect on Tp-e and Tp-e/QT ratio, also, which did not cause any proarrhythmic events in any preparation at any concentration. Conclusion Danghong injection possesses no significant risk of TdP and other proarrhythmias like ventricular tachycardia in the concentration less than or on the verge of 30 times of free therapeutic plasma C_(max).关键词
丹红注射液/兔左心室楔形标本/QRS综合波宽度/QT间期/Tp-e间期Key words
Danhong injection/ rabbit left ventricular wedge preparation/ QRS duration/ QT interval/ Tp-e interval分类
医药卫生引用本文复制引用
薛小临,刘腾先,杨琳,王东琦,崔长琮,严干新..丹红注射液对兔离体左心室心电图及致心律失常作用[J].中国临床药理学杂志,2009,25(6):509-513,5.
