中国临床药理学与治疗学2009，Vol.14Issue(6)：601-612,12.
现代定量药理学的研究进展及展望
Advances in quantitative pharmacology
摘要
Abstract
Quantitative pharmacology, also termed as pharmacometrics, is the scientific discipline that uses mathematical and statistical methods to quantify the interactions between therapeutic drugs and patients. It increasingly plays a critical role in drug development and pharmacotherapy. Model-based drug development (MBDD) is a paradigm and a mindset which promotes the use of modeling to delineate the path and focus of drug development. The utilization of MBDD remains at an early stage in China, but it is clear that Chinese scientists embrace the discipline, and are keen to apply this methodology to drug development. In this review, we first introduce the definition and developmental history of quantitative pharmacology. Furthermore, we discuss the major areas that the present research focuses and the technological advances in the filed, such as population pharmacokinetics/pharmacodynamics, exposure-response (PK-PD) modeling, clinical trial simulation, novel clinical trial designs, biomarker, disease model, trial model, and M&S methodology. Following that, we give a brief introduction to MBDD. Finally, some challenges that pharmacometrican are currently facing, and the possible solutions are discussed.关键词
定量药理学/新药研发/基于模型的新药研发/建模与模拟Key words
quantitative pharmacology (pharmacometrics)/ drug development/ model-based drug development/ modeling and simulation分类
医药卫生引用本文复制引用
黄晓晖,谢海棠,史军,宋建国,郑青山..现代定量药理学的研究进展及展望[J].中国临床药理学与治疗学,2009,14(6):601-612,12.基金项目
安徽省优秀青年科技基金(08040106813) （08040106813）
安徽省高等学校省级教学研究项目(2007jyxm250) （2007jyxm250）
上海市教委重点学科项目(J50303) （J50303）
