中国临床药理学与治疗学2009，Vol.14Issue(6)：659-663,5.
当归补血汤不同配伍的药动学研究
Pharmacokinetic study on different compatibilities of Dangguibuxue Tang
摘要
Abstract
AIM: To explore the changed regularity of the pharmacokinetic parameters in animal plasma of astragaloside Ⅳ and ferulic acid when Astragalus and Angelica were used solely or compatibly in Dang-guibuxue Tang, and to study the rationality of herbaceous compatibility of Dangguibuxue Tang. METHODS: The New Zealand white rabbits or SD rats were administrated with Astragalus, Angelica or Dangguibuxue Tang, respectively. The blood concentrations of ferulic acid in rabbits administrated with Dangguibuxue Tang or Angelica were analysised by HPLC, while the blood concentration of astragaloside IV in rats administrated with Dangguibuxue Tang or Astragalus were analysised by HPLC/MS/MS and the main pharmacokinetics parameters were calculated. RESULTS: Compared with single administration of Angelica, the pharmacokinetic parameters of ferulic acid in rabbit plasma almost did not show any change when administrated with Dangguibuxue Tang. Compared with administration with Astragalus alone , the t_(max) of Astragaloside Ⅳ in rat plasma was decreased significantly [ from (4.00 ± 1.54) h to (2.00 ± 0.95) h] when given Dangguibuxue Tang, and its peak concentration was increased doublely [C_(max) from (60 ± 7) μg/L to (146 ± 27) μg/L)]. CONCLUSION: Angelica increases the vitality of Astragaloside Ⅳ in Astragalus in the body after the combination, and it advances the process of effectiveness of astragaloside Ⅳ, which embodies the adjuvant contribution of ministerial drug of Angelica. The experiment proves the rationality of Dangguibuxue Tang in terms of pharmaeokinetics.关键词
当归补血汤/药物代谢动力学/配伍规律/阿魏酸/黄芪甲苷/HPLC/MS/MSKey words
Dangguibuxue Tang/ pharmacokinetics/ compatibility rule/ ferulic acid/ astragaloside Ⅳ/ HPLC/MS/MS分类
医药卫生引用本文复制引用
王文萍,曹琦琛,王华伟,吕玉萍..当归补血汤不同配伍的药动学研究[J].中国临床药理学与治疗学,2009,14(6):659-663,5.基金项目
辽宁省科技厅"辽宁省重点实验室专项资金--中药药对、中药方剂药物配伍的物质基础及生物效应的研究"项目资助. （）
