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中药对细胞色素P450代谢影响的研究进展

谢瑞芳 周昕

中国临床药理学与治疗学2009,Vol.14Issue(6):697-701,5.
中国临床药理学与治疗学2009,Vol.14Issue(6):697-701,5.

中药对细胞色素P450代谢影响的研究进展

Research progress on traditional Chinese medicine affecting the metabolism of cytochrome P450

谢瑞芳 1周昕1

作者信息

  • 1. 上海中医药大学附属龙华医院药剂科,上海,200032
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摘要

Abstract

Cytochrome P450 is one of the miero-somal mixed function oxidase, and plays an important role in the metabolism of exogenous and endogenous material. Lots of domestic and overseas relative literatures were red, the article summarized the research progress of traditional Chinese medicine affecting the metabolism of CYP in recent years. Eight main drug-metabolizing enzymes were respectively introduced, including CYP1A1, CYP1A2, CYP2A6, CYP2C, CYP2D6,CYP2E1,CYP3A4 and CYP3A4. It is important to research CYP450 for drug screening, individual administration.

关键词

中药/细胞色素P450/研究进展

Key words

traditional Chinese medicine/ CYP/ research in progress

分类

医药卫生

引用本文复制引用

谢瑞芳,周昕..中药对细胞色素P450代谢影响的研究进展[J].中国临床药理学与治疗学,2009,14(6):697-701,5.

基金项目

上海中医药大学校级课题《中药黄芪对2型糖尿病患者CYP450酶系活性的影响》资助 ()

中国临床药理学与治疗学

OACSCDCSTPCD

1009-2501

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