中国临床药理学与治疗学2009，Vol.14Issue(1)：25-31,7.
维生素E对阿尔茨海默病模型学习记忆能力损伤的改善作用
Vitamin E administration improves learning and memory deficits in modeling Alzheimer's disease
赵琳 1何苗 1金万宝 1赵海山 1姚维凡 1魏敏杰1
作者信息
- 1. 中国医科大学药学院药理教研室,沈阳,110001,辽宁
- 折叠
摘要
Abstract
AIM: To investigate the protective effects of Vitamin E on learning and memory in a mouse model of Alzheimer's disease (AD) and the mechanisms. METHODS: Mice were intragastric administrated with D-galactose (D-gal) and sodium nitrite ( NaNO_2) or vehicle, and divided into two main groups which received Vitamin E (28 and 280 IU/kg) at two different time points: either at the same time of admin-istration, or 2 h after D-gal and NaNO_2 dosing. After that,animals were trained and tested learning and memory abilities using the SMG-2 water maze. The changes of AChE and nuclear factor (NF)-κB were de-tected to explore the mechanism of Vitamin E's protective effects on learning and memory deficits. RESULTS: Mice administrated with Vitamin E at the same time of D-gal and NaNO_2 dosing showed a significant decrease in escape latency [ F (3,56) = 6.959 on day 1; F(3,56) = 6.689 on day 2; F(3,56) = 17.379 on day 3; F(3,56) = 13.391 on day 4; P < 0.05], accompanied with significant reduction of MDA [F(3,28)=11.235, P<0.05] and AChE activity [F(3,28)=29.431, P<0.05], increase of SOD activity [F(3,28) =7.372, P<0.05]. Vitamin E also decreased Aβ and NF-κB expressions in the cerebral cortex of AD mice model (P<0.05). However, mice receiving Vitamin E 2 h after D-gal and NaNO_2 dosing can not reverse the learning and memory deficits. CONCLUSION: Preventive administration of Vitamin E could remarkably prevent the learning and memory impairment, the machnism may be to increase the activity of SOD, reduce the activity of ACHE, the levels of MDA and the expressions of Aβ and NF-κB in the brain.关键词
阿尔茨海默病/维生素E/学习记忆损伤/小鼠Key words
Alzheimer's disease/Vitamin E/learning and memory deficits/mice分类
医药卫生引用本文复制引用
赵琳,何苗,金万宝,赵海山,姚维凡,魏敏杰..维生素E对阿尔茨海默病模型学习记忆能力损伤的改善作用[J].中国临床药理学与治疗学,2009,14(1):25-31,7.
