中国输血杂志2009，Vol.22Issue(10)：802-805,4.
负载自体肿瘤抗原的DC-CIK细胞联合自体造血干细胞移植治疗难治性淋巴瘤的临床研究
Autologous tumor cell lysate-loaded dendritic cells and cytokine-induced killer cells in combination with autologous hematopoietic stem cell transplatation in the treatment of refractory lymphoma
苏毅 1邵文军 2闵敏 2李莉 2陈健 2范方教 1易海 1付利 1刘阳阳 1邓涛 1孙浩平 2孙薏 2钟国成2
作者信息
- 1. 成都军区总医院,血液科,四川,成都,610088
- 2. 解放军452医院,血液肿瘤科
- 折叠
摘要
Abstract
Objective To study the efficacy and side effect of autologons tumor cell lysate-loaded DC-CIK plus autologous hematopoietic stem cell transplantation in the treatment of refractory lymphoma.Methods Thirty-five cases of refractory lymphoma were recruited,lymphoma antigen-pulsed autologous DE-CIK cells were infused 5-10 days after the MAC conditioning regimen.Results Out of the 35 Cases,complete remission Was achieved in 29(82.8%),partial remission in 4(14.4%).Two patients died during transplantation due to severe mixed infections,with a transplant-related mortality rate of 5.7%.All cases of complete remission and partial remission were followed-up for 3-49 months,4 cases with partial remission died 3,6,10,13 months after transplantation.Three cases with complete remission relapsed 11,17,20 months after transplantation.and the other 26 cases survived until now.Conclusion Autologous tumor cell lysate-loaded DE-CIK combined with autologous hematopoietic stem cell transplantation in the treatment of refractory lymphoma is safe and effective.关键词
淋巴瘤/DC/CIK/白体造血干细胞/移植/细胞治疗Key words
Lymphoma DE CIK/Autologous hematopoieric stem cell transplantation/Cell therapy分类
医药卫生引用本文复制引用
苏毅,邵文军,闵敏,李莉,陈健,范方教,易海,付利,刘阳阳,邓涛,孙浩平,孙薏,钟国成..负载自体肿瘤抗原的DC-CIK细胞联合自体造血干细胞移植治疗难治性淋巴瘤的临床研究[J].中国输血杂志,2009,22(10):802-805,4.
