中国实用内科杂志2009，Vol.29Issue(11)：1009-1011,3.
急性非淋巴细胞白血病化疗肝损伤发生率及其相关因素研究
The incidence and risk factors of chemotherapy-induced liver disease of the patients with acute non-lymphocytic leukemia
摘要
Abstract
Objective To investigate the incidence and risk factors of chemotherapy-induced liver disease of AML patients. Methods Liver disease was classified into three grades as mild,moderate and severe according to the criteria established on European Drug Conference in 1990. Seventy cases of AML patients were studied who received treatment in the hematological department of General Hospital of Tianjin Medical University from 1997 to 2006. Statistics methods such as Chi-square test and Logistic Regression were used to investigate the correlation between the incidence and the risk factors of liver disease. Results The incidence of liver disease of seventy AML patients was 65.7%, including 38.6% mild,17.1% moderate and 10.0% severe liver disease. Single factor analysis showed that infection,blood transfusion, synchronous use of penicillin,cephalosporins,aminoglycosides, azoles could increase the incidence of liver disease (P<0.05); Liver disease was more common in the treatment of inducing remission and the regimen of ATRA(P <0.05); Glutathione was a protecting factor(P < 0.05). The incidence of liver disease was not significantly correlated with age, gender, types of leukemia, or the regimens(P > 0.05). Multivariate factor analysis showed that infection and synchronous use of cephalosporins were independent risk factors of liver disease(P<0.05). Conclusion The risk factors of chemotherapy-induced liver disease include infection, synchronous use of cephalosporins, treatment of inducing remission, and regimen of ATRA. Prophylactic use of glutathione could decrease the incidence of liver disease.关键词
肝损伤/化疗/白血病/急性/非淋巴性Key words
liver disease/ chemotherapy-induced/leukemia/ acute/ non-lymphocytic分类
医药卫生引用本文复制引用
岳兰竹,关晶,吴玉红,王化泉,邢莉民,李丽娟,王珺,邵宗鸿,付蓉,阮二宝,瞿文,梁勇,王国锦,王晓明,刘鸿,宋嘉..急性非淋巴细胞白血病化疗肝损伤发生率及其相关因素研究[J].中国实用内科杂志,2009,29(11):1009-1011,3.基金项目
天津市科技支撑计划项目(07ZCGYSF00600) （07ZCGYSF00600）
高校博士点基金项目(200800620004) （200800620004）
