中国实用内科杂志2009，Vol.29Issue(11)：1030-1032,3.
慢性乙型肝炎HBV DNA前C区变异检测及其与干扰素治疗关系的研究
Detection of hepatitis B virus pre-C region mutation in cases of chronic hepatitis B and its relationship with IFN treatment
孙国君 1崔巍 1李智伟1
作者信息
- 1. 沈阳药科大学生理教研室,沈阳,110016
- 折叠
摘要
Abstract
Ohjective To investigate the relationship between hepatitis B virus pre-core region 1896 site mutation in cases of chronic hepatitis B and IFN-alpha treatment. Methods 200 patients with chronic hepatitis B were randomly divided into experimental group(n=100) and control group(n=100). The patients in experimental group were treated with regular liver-protective drugs and IFN-alpha, while Control group patients received only regular liver-protective drugs for 6 months. PCR-RFLP were used to detect hepatitis B virus(HBV) DNA with pre-C region 1896 site mutation in two grops pre and post treatment. Results The mutation rates before interferon treatment were 20% (20/100) and 18% (18/100) in experimental group and control group, respectly. After treatment, the effective rates in experimental group were 60% (12/20) and 50% (40/80) in Patients with Chronic Hepatitis B variant and wild strain virus Infection,respectly. The ef-
fective rate in experimental group was significantly higher than that in control group. Conclusion IFN-alpha therapy was not correlated with genomic variability of the core region.关键词
乙型肝炎病毒/基因变异/干扰素-αKey words
HBV DNA/ mutation/ IFN-alpha分类
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孙国君,崔巍,李智伟..慢性乙型肝炎HBV DNA前C区变异检测及其与干扰素治疗关系的研究[J].中国实用内科杂志,2009,29(11):1030-1032,3.
