中国药房2009，Vol.20Issue(31)：2418-2420,3.
3种麻醉剂对兔Oddi括约肌肌电运动的影响
Effect of 3 Kinds of Anaesthetics on the Myoelectric Motility of Sphincter of oddi in Rabbits
刘永康 1李智华 1王冰洋 1何谦 1王小军 1董家鸿1
作者信息
- 1. 第三军医大学西南医院全军肝胆外科研究所,重庆市,400038
- 折叠
摘要
Abstract
OBJECTIVE: To explore the influence of sumianxin, ketamine and sodium pentobarbital on the myoelectric motility of Sphincter of Oddi (SO) . METHODS: 24 adult rabbits were used in this study, and the access to the myoelectric motility recording was achieved by interposition of jejunum stump with modified Thomas method. The survived rabbits were divided into 3 groups after 10 days' recovery time, each group was anesthetized with sumianxin(n = 6), ketamine(n = 5), and sodium pentobarbital(n = 5), respectively. Cholecystokinin (CCK, 20、100 ng ·kg~(-1)) was injected in conscious state and after the rabbits were completely anesthetized 5 min was recorded (the interval between CCK injections was at least 3 min) .The change of myoelctric motility were recorded before and after CCK application without anaesthetics, and the enhancement of motility index and change of effective duration were evaluated. The effects of 3 anaesthetics on the myoelectric motility were compared with the conscious state before anesthesia with or without CCK application. RESULTS: In comparison with the conscious state, myoelectric motility of SO was significantly enhanced in sumianxin and ketamine group(P<0.05), but no significant change was observed in sodium pentobarbital group. Exogenous CCK stimulates the spikes of SO in all rabbits, this effect was significantly weakened by sumianxin and ketamine, whereas sodium pentobarbital totally magnified the excitation role of CCK including increased motility index and prolonged effective duration(P<0.05) . CONCLUSION: All the three drugs alter the myoelectric motility of SO in rabbits, especially for sumianxin and ketamine, while sodium pentobarbital has relatively less influence.关键词
麻醉剂/兔/Oddi括约肌/肌电运动Key words
Anaesthetic/ Rabbit / Sphincter of oddi / Myoelectric motility分类
医药卫生引用本文复制引用
刘永康,李智华,王冰洋,何谦,王小军,董家鸿..3种麻醉剂对兔Oddi括约肌肌电运动的影响[J].中国药房,2009,20(31):2418-2420,3.
