中国药房2009，Vol.20Issue(31)：2434-2436,3.
鬼臼毒素衍生物脂质体处方和制备工艺优选
Optimization of the Formulation and Preparation Technology of Podophyllotoxin Derivative Liposomes
摘要
Abstract
OBJECTIVE: To optimize the formulation and preparation technology of podophyllotoxin derivative(5-FPE) liposomes. METHODS: A thin film-ultrasonic dispersion method was used to prepare the 5-FPE liposomes. Orthogonal experiment was performed to optimize its best formulation and preparation technology with entrapment efficiency as the eval-uation index; meanwhile, the entrapment efficiency, drug-loading amount, morphology, particle size distribution, Zeta electric potential and stabilities of the liposomes within 10 days' storing at 25 ℃ or 4℃ were investigated. RESULTS: The optimal formulation and prepariton technology of the liposomes has been established in our study. 3 batches of liposomes pre-pared in the optimal conditions had a mean entrapment efficiency of 66.45% , a mean drug-loading amount of 7.97% , mean particle size of 284.7 nm and mean Zeta electric potential of - 22.15 mV. The entrapment efficiency of the liposomes decreased more after storing for 10 days at 25 ℃ than at 4 ℃. CONCLUSION: The optimal formulation and preparation technology of 5- FPE liposomes are feasible and which serve as a basis for the further study of 5- FPE preparations.关键词
鬼臼毒素衍生物/脂质体/处方/工艺/优选Key words
Podophyllotoxin derivative/ Liposomes/ Formulation/ Technology/ Optimization分类
医药卫生引用本文复制引用
向蓉,倪京满..鬼臼毒素衍生物脂质体处方和制备工艺优选[J].中国药房,2009,20(31):2434-2436,3.基金项目
甘肃省自然科学基金资助项目(0803RJZA079) （0803RJZA079）
甘肃省新药临床前重点实验室开放基金资助项目(GSKFKT-0602) （GSKFKT-0602）
