中国药房2009，Vol.20Issue(33)：2564-2566,3.
血必净注射液对窒息模型大鼠复苏后心功能、心肌细胞钙离子变化的影响
Effects of Xuebijing Injection on the Cardiac Function and Calcium Ions in Cardiac Myocytes of Rats after Anoxia-induced Cardiac Arrest-Cardiopuimonary Resuscitation (CA-CPR)
摘要
Abstract
OBJECTIVE: To investigate the effect of Xuebijing injection on the cardiac function and calcium ions of cardiocyte in rats after anoxia-induced cardiac arrest-cardiopulmonary resuscitation (CA-CPR) . METHODS: CA-CPR model was in-duced in rats and then the model rats were randomized to 4 groups, i.e. sham group,model group, Xuebijing injection high dose gr-oup(4 mL·kg~(-1)),and Xuebijing injection lowdose group(Xuebijing injection 2mL·kg~(-1)).Mean arterial pressure(MAP), ±LVdp/ dt max, average fluorescence intensity of calcium and pathological changes of cardiocytes were observed at 0 and 6 hours after re-suscitation, respectively. RESULTS: Compared with model group, Xuebijing ingeetion high dose group at 6 h showed significantly increased MAP(P<0.01); Xuebijing injection high dose group and Xuebijing injection low dose group showed significantly lower±LVdp/dt max (P<0.01) and significantly higher average fluorescence intensity of calcium of cardioeytes(P<0.01).Microscopically, the damage of myocardial injury in Xuebijing injection high dose group was attenuated. CONCLUSION: Xuebijing injection can improve cardiac dysfunction after eardiopulmonary resuscitation, inhibit calcium overload in myocardial cells and attenuate the myocardial damage.关键词
窒息/心肺复苏/心功能/钙离子/缺血/再灌注损伤/血必净注射液Key words
Anoxia/Cardiopulmonary resuscitation/ Cardiac function/ Calcium ion/ Ischemia-reperfusion injury/ Xuebijing injection分类
医药卫生引用本文复制引用
周厚荣,张谦,刘海健,杨秀林..血必净注射液对窒息模型大鼠复苏后心功能、心肌细胞钙离子变化的影响[J].中国药房,2009,20(33):2564-2566,3.基金项目
贵州省科技计划课题(黔科合S字[2007]1055) （黔科合S字[2007]1055）
贵州省优秀科技教育人才省长专项资金项目(黔省专合字(2007)66号) （黔省专合字(2007）
