中国药房2009，Vol.20Issue(33)：2575-2576,2.
大根草提取物对模型大鼠心肌缺血的保护作用研究
Protective Effect of Geum japonicum Extract on Myocardial Ischemia Induced by Isoprenaline in Rats
张玉玺 1姚晓颖 1肖艳 1程晓慧 1李士峰 1王敏伟2
作者信息
- 1. 大庆油田总医院,大庆市,163001
- 2. 沈阳药科大学,沈阳市,110016
- 折叠
摘要
Abstract
OBJECTIVE: To explore the protective effect of Geum japonicum extract on isoprenaline-induced myocardial ischemia in rats. METHODS: The myocardial ischcmia rat model was developed by using isoprenaline. The ECG of the model rats was recorded and the activities of AST, CPK, LDH and SOD and the content of MDA in rats were measured. RESULTS: In Isoprenaline-induced myocardial ischemia model rats, G.japonicum extract markedly inhibited the ST segment drift on electrocardiograph, markedly increased SOD activity but significantly lowered the activities of AST, CPK, LDH and the con-tent of MDA.CONCLUSION: G.japonicum extract has strong anti-myocardial ischemia effect.关键词
大根草提取物/心肌缺血/异丙肾上腺素/超氧化物歧化酶/丙二醛Key words
Geum japonicum extract/ Myocardial ischemia/ Isoprenaline/ SOD/ MDA分类
医药卫生引用本文复制引用
张玉玺,姚晓颖,肖艳,程晓慧,李士峰,王敏伟..大根草提取物对模型大鼠心肌缺血的保护作用研究[J].中国药房,2009,20(33):2575-2576,2.
