中国药房2009，Vol.20Issue(33)：2586-2588,3.
丹参多酚酸口腔崩解片处方及工艺研究
Formulation and Preparation Technology of Salvianolic Acid Orally Disintegrating Tablets
摘要
Abstract
OBJECTIVE: To study the formulation and preparation technology of salvianolic acid orally disintegrating tablets. METHODS: Single-factor method was employed to optimize the pressure, lubricant and correctant; and orthogonal design was employed to optimize the disintegrant and wetting agent. RESULTS: The optimized formulation was as follows: 34.3 N (pressure), 12% salvianolate acid, 56% starch, 0.5% magnesium stearate, 5% aspartame, 0.5% fruit essences, 25% disintegrant(I.e. 20% microcrystalline cellulose, 5% low-substituted hydroxypropyl cellulose), 7% crospovidone, and 6% polyvinylpyrrolidone K 30.The prepared tablets disintegrated totally within 23.5 s and tasted good. CONCLUSION: The op-timized preparation technology is simple and convenient, and the preparation is up to the standard.关键词
丹参多酚酸/口腔崩解片/正交设计/制剂处方Key words
Salvianolic acid/ Orally disintegrating tablets/ Orthogonal design/ Formulation分类
医药卫生引用本文复制引用
周毅生,孟江,成银库,廖华卫,段芳,刘林..丹参多酚酸口腔崩解片处方及工艺研究[J].中国药房,2009,20(33):2586-2588,3.基金项目
广东省科技计划项目(2006B35603003) （2006B35603003）
