中国药房2009，Vol.20Issue(28)：2179-2181,3.
东宝肝泰片防治大鼠酒精性脂肪肝的作用及机制研究
Action Mechanism of Dongbaogantai Tablet in the Prevention and Treatment of Alcoholic Fatty Liver in Rats
摘要
Abstract
OBJECTIVE: To investigate the mechanism of the prevention and treatment effects of dongbaogantai tablet (DT)on rats with alcoholic fatty liver (AFL). METHODS: SD rats were randomly divided into normal control group, model group and DT group. The model group and DT group were administered intragastrically with alcohol and fed with high fat diet for 8 weeks to replicate AFL model, meanwhile the model group were administered intragastrically with normal saline and DT group with DT synchronously for 8 weeks. Levels of TG, CHO, LDL- C, HDL- C, AST and ALT in serum, and MDA, NEFA, SOD and GSH- PX in hepatic tissue were detected and the pathological changes of liver were observed under light microscope. RESULTS: In DT group compared with model group, serum levels of TG, CHO, LDL- C, AST, ALT, MDA and NEFA were significantly down- regulated (P<0.05), but levels of HDL- C, SOD and GSH- PX were significantly upregulated (P<0.05) ; however, the pathological changes of liver were similar to those in normal control group. CONCLUSION: DT can effectively prevent and treat AFL by reducing the lipid peroxidation.关键词
东宝肝泰片/酒精性脂肪肝/防治/大鼠Key words
Dongbaogantai tablet/ Alcoholic fatty liver/ Prevention and treatment/ Rat分类
医药卫生引用本文复制引用
朱卫丰,赵益,许可敏,石敏娟,陈丽华..东宝肝泰片防治大鼠酒精性脂肪肝的作用及机制研究[J].中国药房,2009,20(28):2179-2181,3.基金项目
江西省卫生厅中医药科研计划项目(2003A59) （2003A59）
