中国药房2009，Vol.20Issue(28)：2211-2212,2.
丹皮酚-SPE_7-β-CD包合物片剂的处方研究
Optimization of the Formulation of Paeonol-SPE_7-β-CD Inclusion Complex Tablets
邓步华 1张荣发 1杨宗发1
作者信息
- 1. 重庆医药高等专科学校,重庆市,400030
- 折叠
摘要
Abstract
OBJECTIVE: To optimize the formulation of paeonol- SPE_7-β-CD inclusion complex tablets. METHODS: The formulation was optimized by orthogonal test with dissolution rate serves as index and the amount of adhesive (10% starch paste), disintegrant (dry starch) and lubricant (magnesium stearate) served as major factors, meanwhile a verification test was conducted. RESULTS: The optimum formulation of paeonol -SPE_7-β - CD inclusion complex tablets was as follows: paeonol - SPE_7-β - CD 106.2 g, lactose 48.7 g, 10% starch paste 3.0 g, dry starch 6.0 g, and magnesium stearate 0.1g. The mean dissolution rate was 95.56% for three hatches of samples prepared under the above condition. CONCLUSION: The optimized formulation is ideal and feasible.关键词
丹皮酚-SPE_7-β-CD包合物片剂/处方设计/正交试验/溶出度Key words
Paeonol-SPE_7-β-CD inclusion complex tablets/ Formulation design/ Orthogonal test/ Dissolution rate分类
医药卫生引用本文复制引用
邓步华,张荣发,杨宗发..丹皮酚-SPE_7-β-CD包合物片剂的处方研究[J].中国药房,2009,20(28):2211-2212,2.
