洛伐他汀片溶出度测定OA北大核心CSCDCSTPCD
Determination of the Dissolution of Lovastatin Tablets
目的:建立测定洛伐他汀片剂溶出度的方法,并以此考察不同厂家洛伐他汀片剂的溶出度.方法:含量测定方法为高效液相色谱法,色谱柱为Alltima C_(18),流动相为乙腈-0.01%磷酸(60:40),检测波长为238nm;溶出度测定方法采用桨法,以2%十二烷基硫酸钠-磷酸盐缓冲溶液(pH 7.0)为溶出介质,转速为50 r·min~(-1),取样时间为30 min.对6个厂家12批样品进行了溶出度测定.结果:洛伐他汀检测浓度线性范围为4.88～19…查看全部>>
OBJECTIVE: To establish a method for determination of the dissolution of lovastatin tablets and to investigate the dissolution of it from different manufactures. METHODS: HPLC was employed for content determination with Alltima C_(18) chromatographic column, and the mobile phase consisted of acetonitrile- 0.01% phosphoric acid (60 : 40) with the detective wavelength set at 238 nm. The dissolution was determined by paddle method with 2% sodium lauryl sulphate…查看全部>>
高燕霞;张西如;张菁;姜建国
河北省药品检验所,石家庄市,050011河北省药品检验所,石家庄市,050011河北省药品检验所,石家庄市,050011河北省药品检验所,石家庄市,050011
医药卫生
洛伐他汀片剂溶出度高效液相色谱法
Lovastatin Tablets Dissolution HPLC
《中国药房》 2009 (28)
2219-2221,3
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