中国药房2009，Vol.20Issue(29)：2299-2301,3.
左卡尼汀对维持性血液透析患者血清总同型半胱氨酸的影响
Effect of L- carnitine on Serum Total Level of Homocysteine in Patients Undergoing Maintenance Hemodialysis
解德琼 1杜一平 1刘牧 1曾立 1朱磊1
作者信息
- 1. 四川宜宾市第二人民医院肾内科,宜宾市,644000
- 折叠
摘要
Abstract
OBJECTIVE: To evaluate the effect of L-carnitine on serum total level of homocysteine (tHcy) in patients undergoing maintenance hemodialysis. METHODS: 60 patients undergoing maintenance hemodialysis were randomly divided into two groups (treatment group and control group): the patients in the treatment group were injected i.v. with 1.0 g of L-carnitine for 12 weeks, and those in the control group were injected i.v. with 5 mL normal saline for 12 weeks. Meanwhile,the healthy people were involved as normal control group(n =20) . tHcy was detected by ELISA method; the fasting insulin was detected by radio- immunity method. Fasting blood glucose, total cholesterol, triglyeride, HDL and LDL were detected by routine method. The reciprocal of the multiplication product between fasting blood glucose and insulin concentration were computed as insulin sensitivity index(ISI) . RESULTS: After treatment for 12 weeks, the treatment group showed increased ISI but significantly reduced tHcy (P< 0.05); however, no significant differences of ISI.tHcy were noted in the control group before and after treatment. CONCLUSION: Insulin resistance and high tHcy present in patients undergoing maintenance hemodialysis can be reversed by L - carnitine.关键词
同型半胱氨酸/尿毒症/左卡尼汀/维持性血液透析Key words
Homocysteine/ Uremia/ L-carnitine/ Maintenance hemodialysis分类
医药卫生引用本文复制引用
解德琼,杜一平,刘牧,曾立,朱磊..左卡尼汀对维持性血液透析患者血清总同型半胱氨酸的影响[J].中国药房,2009,20(29):2299-2301,3.
