中国医科大学学报2009，Vol.38Issue(10)：775-777,3.
骨桥蛋白和基质金属蛋白酶9在上皮性卵巢癌中的表达及二者相关性
Expression and Relationship of OPN and MMP-9 in Epithelial Ovarian Carcinoma
摘要
Abstract
Objective To study the expression and relationship of osteopontin (OPN) and matrix metalloproteinase-9 (MMP-9) in epithe-lial ovarian carcinoma. Methods Immunohistochemical staining S-P methods was used to detect the expression of OPN and MMP-9 in the samples of 60 epithelial ovarian carcinoma,20 benign ovarian tumor,20 borderline ovarian tumor and 10 normal ovarian tissue. Results The expression level of OPN and MMP-9 in epithelial ovarian carcinoma(109.86±21.51) were significantly higher than those in borderline ovarian tumor(45.81±8.93),benign ovarian tumor(11.86±3.01) and normal ovarian tissue(5.32±2.74). The expression level of OPN and MMP-9 related to the tumor grading,tumor stage and lymph node metastasis,while had no relationship with histological grading. There was significant positive correlation between OPN and MMP-9 in epithelial ovarian carcinoma (r = 0.80,P < 0.05). Conclusion The increased expression of OPN and MMP-9 may play an important role in the process of carcinogenesis, progression and differentiation of epithelial ovari-an carcinoma. OPN and MMP-9 may be a useful targets for treatment of ovarian carcinoma.关键词
骨桥蛋白/基质金属蛋白酶9/上皮性卵巢癌/免疫组织化学Key words
osteopontin/matrixmetallopoteinase-9/epithelial ovarian carcinoma/immunohistochemistiy分类
医药卫生引用本文复制引用
戴宇,焦伊胜,王永来..骨桥蛋白和基质金属蛋白酶9在上皮性卵巢癌中的表达及二者相关性[J].中国医科大学学报,2009,38(10):775-777,3.基金项目
辽宁省教育厅科学研究计划项目(208776,05L475) （208776,05L475）
沈阳市科委科学研究计划项目(1081239) （1081239）
