中国肿瘤生物治疗杂志2009，Vol.16Issue(5)：498-502,5.DOI:10.3872/j.issn.1007-385X.2009.05.015
人食管鳞状细胞癌组织中GRP78的表达及其与肿瘤生物学行为的关系
Glucose-regulated protein 78 expression in human esophageal squamous cell carcinoma and its correlation with tumor biological behavior
许鹏 1王丹云 1王宗明 1张志平 1沈令广 1杨长征1
作者信息
- 1. 山东大学附属济南市中心医院,胸外科,山东,济南,250013
- 折叠
摘要
Abstract
Objective: To investigate the expression of glucose-regulated protein 78 in human esophageal squamous cell carcinoma and normal esophageal tissues, and to evaluate its correlation with clinical pathological characteristics of esophageal squamous cell carcinoma. Methods: Fifty-nine specimens of human esophageal squamous cell carcinoma and twenty adjacent normal specimens were collected from the patients who received operation for esophageal squamous cell carcinomas in our Hospital between Oct. 2007 and Nov. 2008. GRP78 mRNA and GRP78 protein expressions were examined by RT-PCR assay and Western blotting, respectively. The relationship between GRP78 expression with clinical parameters of patients, such as gender, length of tumor, tumor infiltration depth, tumor differentiation grade stage, and lymphatic metastasis, was analyzed. Results: GRP78 mRNA and GRP78 protein expression levels in human esophageal squamous cell carcinoma were significantly higher than those in the normal esophageal tissues (all P<0.01). GRP78 expression in esophageal squamous cell carcinoma tissues was correlated with the infiltration depth, grade of differentiation(P<0.05 or P<0.01), stage of tumors (P<0.01), and lymphatic metastasis (all P<0.01), but not with gender or the length of tumor (P>0.05). Conclusion: GRP78 participates in the development, progress of esophageal squamous cell carcinomas, and its expression is positively associated with the malignancy of carcinoma. GRP78 may be taken as a potential biomarker in evaluating the malignancy of esophageal squamous cell carcinoma.关键词
葡萄糖调节蛋白78/食管肿瘤/鳞状细胞癌/生物分子标志物Key words
glucose-regulated proteins 78 (GRP 78)/ esophageal neoplasms/ squamous cell carcinoma/ biological marker分类
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许鹏,王丹云,王宗明,张志平,沈令广,杨长征..人食管鳞状细胞癌组织中GRP78的表达及其与肿瘤生物学行为的关系[J].中国肿瘤生物治疗杂志,2009,16(5):498-502,5.
