中国肿瘤生物治疗杂志2009，Vol.16Issue(5)：512-515,4.DOI:10.3872/j.issn.1007-385X.2009.05.018
脊柱浆细胞骨髓瘤中骨桥蛋白的表达及其临床意义
Expression of osteopontin in spinal plasma cell myeloma patients and its clinical significance
摘要
Abstract
Objective: To investigate the expression of osteopontin (OPN) in spinal plasma cell myeloma (PCM) and its relationship with the clinicopathological characteristics and prognoses of PCM patients. Methods: Forty-one PCM and 14 spinal simple bone cysts samples were obtained from Affiliated Changzheng Hospital of Second Military University (1998-2006) after surgery. The expression of OPN was determined by streptavidin-perosidase (S-P) immunohistochemical staining. Results: (1) The positive expression rate of OPN in spinal PCM tissues was 82.93% (34/41), and it was absent in spinal simple bone cyst tissues(P<0.01). (2) The expression of OPN in spinal PCM tissues was correlated with clinical and M-component classifications of PCM (P<0.05)，but was not correlated with the type of light chain, pathological stage, age or gender of patients (P>0.05). (3) The overall survival rate of OPN positive PCM patients was higher than that of OPN negative patients (P<0.01). Conclusion: OPN negative PCM patients are liable to have a poor prognosis. The clinical and M-component classifications combined with detection of OPN expression in PCM patients maybe used for predication of prognoses of PCM patients.关键词
浆细胞骨髓瘤/脊柱/骨桥蛋白/预后Key words
plasma cell myeloma/ spina/ osteopontin/ prognosis分类
医药卫生引用本文复制引用
王良哲,刘惠敏,杨志慧,何金,曹旭,刘方方,孙静,朱维健,陈兵..脊柱浆细胞骨髓瘤中骨桥蛋白的表达及其临床意义[J].中国肿瘤生物治疗杂志,2009,16(5):512-515,4.基金项目
第二军医大学长征医院青年科研启动基金(No.200915).Supported by the Scientific Research Starting Foundation for Young Scholars in Affiliated Changzheng Hospital of Second Military Medical University (No. 200915) （No.200915）
