中华医学杂志（英文版）2009，Vol.122Issue(20)：2438-2443,6.DOI:10.3760/cma.j.issn.0366-6999.2009.20.008
Stereotactic localization and visualization of the subthalamic nucleus
Stereotactic localization and visualization of the subthalamic nucleus
摘要
Abstract
Background The subthalamic nucleus (STN) is widely recognized as one of the most important and commonly targeted nuclei in stereotactic and functional neurosurgery. The success of STN surgery depends on accuracy in target determination. Construction of a digitalized atlas of STN based on stereotactic MRI will play an instrumental role in the accuracy of anatomical localization. The aim of this study was to investigate the three-dimensional (3D) target location of STN in stereotactic space and construct a digitalized atlas of STN to accomplish the visualization of the STN on stereotactic MRI, thus providing clinical guidance on the precise anatomical localization of STN.Methods One hundred and twenty healthy people volunteered to be scanned by 1.5 Tesla MRI scanning with 1-mm-thick slice in the standard stereotactic space between 2005 and 2006. One adult male was selected for 3D reconstruction of STN. The precess of 3D reconstruction included identification, manual segmentation, extraction,conservation and reconstruction.Results There was a significant correlation between the coordinates and age (P <0.05). The volume of left STN was significantly larger than the right STN, and there was a significant negative correlation between volume and age (P <0.05).The surface of the STN nucleus after 3D reconstruction appeared smooth, natural and realistic. The morphological feature of STN on the individual brain could be visualized directly in 3D. The 3D reconstructed STN could be rotated,zoomed and displayed at any direction in the stereotactic space. The anteroposterior diameter of the STN nucleus was longer than the vertical and transverse diameters in 3D space. The 3D reconstruction of STN manifested typical structure of the "dual lens".Conclusions The visualization of individual brain atlas based on stereotactic MRI is feasible. However, software for automated segmentation, extraction and registration of MR images need to be further developed.关键词
subthalamic nulcleus/ visualization/ stereotaxis/ brain atlasKey words
subthalamic nulcleus/ visualization/ stereotaxis/ brain atlas分类
医药卫生引用本文复制引用
SHEN Wei-gao,WANG Hai-yang,LIN Zhi-guo,SHEN Hong,CHEN Xiao-guang,FU Yi-li,GAO Wen-peng..Stereotactic localization and visualization of the subthalamic nucleus[J].中华医学杂志（英文版）,2009,122(20):2438-2443,6.基金项目
This study was supported by National Natural Science Foundation of China (No. 30770595) and Key Scientific and Technological Project in Heilongjiang Province (No. GB06C40302). （No. 30770595）
