肿瘤防治研究2009，Vol.36Issue(11)：925-927,3.DOI:10.3971/j.issn.1000-8578.2009.11.007
口腔鳞癌中肿瘤坏死因子-α表达与肿瘤血管生成的关系
Correlation between Expressions of Tumor Necrosis Factor-α anti Angiogenesis in Human Oral Squamous Cell Cancer
摘要
Abstract
Objective Many investigations have showed that tumor necrosis factor-α(TNF-a)participated into tumor angiogenesis. By exploring the expression of TNF-α and angiogenesis in oral squamous cell cancer(OSCC) and pericancerous tissue, we studied the correlation of the expression of TNF-α and angio-genesis. Methods The expression of TNF-α and microvessel counts were assessed by immunohistochemi-cal methods of SABC in paraffin section of 41 OSCC and 10 cases of pericancerous tissues. Results The expression of TNF-α in the OSCC group was significantly higher than that in the pericancerous group(P <0.01); microvessel counts in OSCC group was higher than that in the pericancerous group(P<0.01).The expression of TNF-α was significantly correlated to the microvessal counts(P<0.01). Conclusion TNF-α play a key role in angiogenesis of OSCC. But its mechanism and clinical significance need further investigations.关键词
口腔鳞癌/肿瘤血管生成/肿瘤坏死因子a(TNF-a)Key words
Oral squamous cell cancer/ Angiogenesis/ Tumor necrosis factor-α分类
医药卫生引用本文复制引用
杨建斌,邵月保,魏东义,冯红超,宋宇峰..口腔鳞癌中肿瘤坏死因子-α表达与肿瘤血管生成的关系[J].肿瘤防治研究,2009,36(11):925-927,3.基金项目
贵州省第二批跨世纪人才省政府专项基金资助项目[黔科合人专字(2000)9813号] （2000）
