中药材2009，Vol.32Issue(10)：1568-1571,4.
豹皮樟总黄酮对高脂血症大鼠胰岛素抵抗的改善作用及其机制研究
Effects and Mechanisms of Total Flavonoids of Litsea coreana on Insulin Resistance in Rats with Hyperlipidemia
摘要
Abstract
Objective: To study the effects and its mechanisms of total Flavonoids of Litsea Coreana(TFLC)on insulin resistance (IR)in rats with hyperlipidemia. Methods: The rats were fed with high fat emulsion to make IR models. The effects of TFLC on the state of impaired glucose tolerance (IGT), fasting serum glucose (FSG), fasting serum insulin (FINS), fasting serum lipids (TC, TG, LDL-C, HDL-C), free fatty acid(FFA) and Leptin were observed, and the index of insulin sensitivity (ISI) was calculated. Results: TFLC could significantly improve the state of IGT and depress the level of FSG, FINS, TC, TG, LDL-C, FFA and Leptin of model rats, which could also increase the content of HDL-C and ISI significantly and enhance the sensitivity of insulin. Conclusion:TFLC has obvious effects on increasing insulin sensitivity and improving the insulin resistance in rats with hyperlipidemia, which may contribute to the regulating effects on the disturbance of lipid metabolism and the decrease of Leptin level.关键词
豹皮樟总黄酮/高脂血症/胰岛素抵抗Key words
Total flavonoids of Litsea coreana/ Hyperlipidemia/ Insulin resistance分类
医药卫生引用本文复制引用
吕雄文,李俊,金涌,张磊,王建青..豹皮樟总黄酮对高脂血症大鼠胰岛素抵抗的改善作用及其机制研究[J].中药材,2009,32(10):1568-1571,4.基金项目
安徽省教育厅自然科学研究项目(2004kj195) （2004kj195）
安徽省高等学校青年教师科研资助计划自然科学项目(2004jq164) （2004jq164）
