中药材2009，Vol.32Issue(10)：1577-1579,3.
穿心莲内酯对实验性糖尿病大鼠血糖的影响及其分子机制
Effects of Angrographolide on Plasma Glucose Level of Experiment Diabetic Rats and Its Molecular Mechanism
摘要
Abstract
Objective: To investigate the effects of Angrographolide on plasma glucose level of diabetic rats and its molecular mechanism. Methods: The diabetic model rats were established by intraperitoneal injection of streptozotocin (65 mg/kg). Diabetic rats were treated with Angrographolide for 2 weeks, then the activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in serum were examined and the expressions of Bcl-2 and Box gene of Pancreatic Cells were detected. Results: Compared with model rats, the plasma glucose levels and the serum MDA contents of the Angrographolidetreated rats decreased, serum insulin and activity of SOD increased significatantly (P＜0. 01). The expression of Bcl-2 was lower in the model group, while the expression was stronger in the treatment group (P ＜0. 05). Conclusion: Angrographolide can inhibit the apoptosis of islet cells and depress plasma glucose level of diabetic rat model. Its mechanism may be associated with the upregulation of the expression of Bcl-2, the increase of the activity of SOD, the decrease of the production of free radicals and lipid eroxidadion.关键词
穿心莲内酯/糖尿病大鼠/血糖/分子机制Key words
Angrographolide/ Diabetic rats/ Plasma glucose/ Molecular mechanism分类
医药卫生引用本文复制引用
杨苹,陈森洲,肖胜军,侯巧燕,周英琼,冯梅,李莉..穿心莲内酯对实验性糖尿病大鼠血糖的影响及其分子机制[J].中药材,2009,32(10):1577-1579,3.基金项目
广西省教育厅基金资助项目(0626137) （0626137）
广西科技厅基金项目(0728232) （0728232）
