中国肺癌杂志2011，Vol.14Issue(9)：727-732,6.DOI:10.3779/j.issn.1009-3419.2011.09.07
基于雌激素受体信号通路的肺癌靶向治疗研究进展
Advances of Targeted Therapy Based on Estrogen Receptor Signaling Pathway in Lung Cancer
摘要
Abstract
Increasing evidence indicates that estrogen promotes tumor growth in both estrogen target organs and non-target organs. Estrogen regulates cell proliferation and differentiation via two different receptors; estrogen receptors a and β (Era and Erβ). In recent decades, with the clarification of the Era-mediated signaling pathways in breast cancer, targeted therapy through these pathways have successfully been used in clinical application. Tamoxifen; the classic representative, is a selective estrogen receptor modulator (SERM). Along with the elucidation of the role of estrogen in the pathophysiology of lung cancer, targeted lung cancer treatment based on the ER signaling pathways is also gradually being applied and it could become an important part of the comprehensive treatment for lung cancer.关键词
雌激素受体/肺肿瘤/靶向治疗Key words
Estrogen receptor/ Lung neoplasms/ Targeted therapy分类
医药卫生引用本文复制引用
徐利强,廖永德,唐和孝,张超,刘昭国..基于雌激素受体信号通路的肺癌靶向治疗研究进展[J].中国肺癌杂志,2011,14(9):727-732,6.基金项目
本研究受国家留学人员科技活动项目择优项目(人社厅发[2008]86号)资助 （人社厅发[2008]86号）
