中国卒中杂志2011，Vol.6Issue(9)：711-716,6.
循环内皮祖细胞异位表达骨钙素在缺血性脑血管病发病中的作用
Abnormal Expression of Osteocalcin on Circulating Endothelial Progenitor Cells in Patients with Ischemic Cerebrovascular Diseases
刘力 1李芬娥 2王雅杰 1刘志忠 1康熙雄1
作者信息
- 1. 100050,北京市,首都医科大学附属北京,天坛医院检脸科
- 2. 北京市仁和医院检验科
- 折叠
摘要
Abstract
Objective To explore whether endothelial progenitor cells(EPCs) in patients with cerebrovasculardiseases could express high level of osteocalcin.Methods We studied 51 patients with acute cerebrovascular diseases and 30 sex- and age- matchedcontrol subjects. EPCs in peripheral blood mononuclear cells were analyzed by flow cytometry.Results Patients with cerebral ischemia had about three-fold increase of the number and thepercentage of osteocalcin positive(OCN+) EPCs compared with control group(P<0.01). Patients withvessel calcification had higher percentage of OCN+EPCs than those without calcification(P=0.033).However, the degree of stenosis had no direct correlation with osteocalcin expression(P=0.672).Logistic analysis showed that the percentage of OCN+EPCs was an independent risk factor forcerebral ischemia(odds ratio=1.143,95% confidence intervals 1.060-1.232).Conclusion Circulating endothelial progenitor cells in patients suffering from cerebral ischemiacan express osteocalcin and act as a negative factor for vascular lesion rather than normal repair.The percentage of OCN+EPCs may be used as a potential cell marker for ischemic cerebrovasculardiseases.关键词
脑梗死/骨钙素/钙质沉着症/干细胞/动脉粥样硬化Key words
Brain infarction/Osteocalcin/Calcinosis/Stem cells/Atherosclerosis引用本文复制引用
刘力,李芬娥,王雅杰,刘志忠,康熙雄..循环内皮祖细胞异位表达骨钙素在缺血性脑血管病发病中的作用[J].中国卒中杂志,2011,6(9):711-716,6.
