摘要
Abstract
Objective To study the express and clinical significance of serum interleukin-18 (IL-18), vascular en-dothelial growth factor (VEGF) and transforming growth factor -β1 (TGF-β1 ) in HBV/HCV/HIV co-infection patients . Methods Serum IL-18, VEGF and TGF-β1 levels in patients with HBV/HCV/HIV co-infection or simple HBV or HCV infection were detected with ELISA method,and liver function biochemical indicators of alanine trans-aminase(ALT), aspartate aminotransferase (AST), gamma glutamyl transferase(GGT) levels were simultaneously detected , correlation between these indicators and IL-18, VEGF, TGF-β1 was analyzed;30 healthy people were randomly selected as control group .statistical analysis was made. Results Serum IL-18, VEGF, and TGF-β1 values in patients with HBV/HCV/HIV co-infection were not associated with gender (P>0. 05), which were significantly higher than that of simple HBV or HCV infection and normal control group (P<0. 01), and was the highest in patients with HBV+ HCV+ HIV co-infection (IL-18, VEGF,TGF-βl evels were [312. 44 ±45. 24]pg/L,[326. 43 ± 51. 24]pg/mL and [283. 51 ± 49. 27]μg/L, respectively) .followed by HCV + HIV co-infection, which were ([224.32±34.37]pg/L,[257.72±47.72]pg/mLand[204.11±43.28]μg/L. Respectively), HBV+ HIV co-in-fection were ([129. 44 ± 27. 62]pg/L, [147. 67 ± 41. 22] pg/mL and [120. 47 ± 30. 23]μg/L respectively). In patients with HBV/HCV/HIV co-infection ,serum IL-18, VEGF, and TGF-β1, levels were positively correlated with ALT, AST, and GGT (r value was 0. 667, 0. 652, 0. 672; 0. 643, 0. 618. 0. 623; 0. 712, 0. 673 and 0. 705, respectively). Conclusion Detection of serum IL-18, VEGF,and TGF-β1, levels are important to evaluate the status of patients with HBV/HCV/HIV co-infection .关键词
肝炎病毒,乙型/肝炎病毒,丙型/人免疫缺陷病毒/合并感染/白细胞介素18/血管内皮生长因子/转化生长因子β1/血传病原体Key words
hepatitis B virus/hepatitis C virus/human immunodeficiency virus sco-infection/interleukin-18/vascular endothelial growth factor/transforming growth factor-β1/blood transmitted disease分类
医药卫生
