中国感染控制杂志2011，Vol.10Issue(4)：269-271,3.
重症监护室耐甲氧西林金黄色葡萄球菌耐药性及联合药敏分析
Drug resistance and antimicrobial combination against methicillin-resistant Staphylococcus aureus isolated from ICU patients
刘家云 1徐修礼 1张鹏亮 1樊新 1孙怡群1
作者信息
- 1. 第四军医大学西京医院全军临床检验医学中心,陕西西安710032
- 折叠
摘要
Abstract
Objective To investigate drug resistance and antimicrobial combination against 38 strains of methicil-lin-resistant Staphylococcu aureus (MRSA) isolated from intensive care unit (ICU) patients, so as to select rational antimicrobial agents to treat MRSA infection. Methods The isolates were identified by VITEK-2 automatic bacterial identification system and Staphylococcus aureus latex coagulation method, MRSA were detected with Staphylococcus aureus latex coagulation method. Drug susceptibility tests were performed with micro-broth dilution method based on Clinical and Laboratory Standards Institute (CLSI) Standard . Results Thirty-eight MRSA stains were sensitive to linezolid (LZD), vancomycin (VAN), and teicoplanin (TEC); the resistant rate to levofloxacin (LVX) and rifampicin (RIF) was 100. 00% and 78. 95% respectively. The fractional inhibitional concentration (FICX1 of RIF combining with LZD, VAN and TEC was 13.16% - 31. 58%; The FIC<1 of LVX combining with LZD, VAN and TEC was 2. 63% - 36. 84%, the difference between antimicrobial combination had statistical significance (P< 0. 01). Conclusion Rational choice of antimicrobial agents to treat MRSA infection in ICU patients should be according to antimicrobial agents and patients' state.关键词
重症监护室/耐甲氧西林金黄色葡萄球菌/抗菌药物/抗药性,微生物/最低抑菌浓度/联合用药Key words
intensive care unit/methicillin-resistant Staphylococcus aureus/antimicrobial resistance/drug resistance , microbial/minimum inhibiting concentration/antimicrobial combination分类
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刘家云,徐修礼,张鹏亮,樊新,孙怡群..重症监护室耐甲氧西林金黄色葡萄球菌耐药性及联合药敏分析[J].中国感染控制杂志,2011,10(4):269-271,3.
