摘要
Abstract
Objective To realize the isolation status of fastidious bacteria causing respiratory tract infection and antimicrobial susceptibility of fastidious bacteria to cefditoren pivoxil as well as the other 9 antimicrobial agents* so as to provide reference for clinical treatment. Methods Fastidious bacteria isolated from sputum of patients with respiratory tract infection during the year of 2005, 2007, 2008, and January-June in 2010 were collected. Antimicrobial susceptibility of fastidious bacteria were tested with Kirby-Bauer method recommended by Clinical and Laboratory Standards Institute (CLSI). Results A total of 462 isolates were isolated from 438 patients, β-lactamase-pro-ducing rate was as follows: Haemo philus in fluenzae (HI) 23. 62% (30/127), Haemophilusparainfluenzae (HP) 2.51%(5/199), Moraxella catarrhalis (MC) 41.58% (42/101), penicillin-resistant Streptococcus pneumoniae (SP) isolates was not found. The susceptibility rate (SR) of HI, HP, MC, and SP to cefditoren pivoxil was 96.30%, 94.36%, 100.00%, and 100. 00%, respectively;The SR of HI and HP to cefotaxime, cefuroxime, cefa-clor and cefazolin was 83. 59% - 93. 33%, SR to amoxicillin/clavulanic acid was 91. 67% and 88. 21 % respectively; SR of MC and SP to amoxicillin / clavulanic acid was 100. 00%; SR of HI to clarithromycin was 87. 96%,SR of HP, SP and MC to clarithromycin was 34. 29% - 59. 00%; SR of 4 kinds of fastidious bacteria to tetracycline was 22.86% - 63. 00%; The resistant rate of HI, HP and MC to trimethoprim/sulfamethoxazole was 54. 63% -3. 33%. Conclusion Cefditoren pivoxil has strong activity against fastidious bacteria causing respiratory tract infection; in order to reduce the emergence of drug-resistant strain, clinicians should choose antimicrobial agents accord-ing to antimicrobial susceptibility test results.关键词
头孢妥仑匹酯/呼吸道感染/苛养菌/抗菌药物/抗药性,微生物/微生物敏感性试验Key words
cefditoren pivoxil/respiratory tract infection/fastidious bacteria/antimicrobial agents/drug resistance, microbial/antimicrobial susceptibility test分类
医药卫生
