广东药学院学报2011，Vol.27Issue(4)：351-353,3.DOI:10.3969/j.issn.1006-8783.2011.04.004
胰岛素眼用温度敏感即型凝胶的制备及其体外释药考察
Study on the preparation and drug release in vitro of in-situ temperature sensitive gel of insulin
王军1
作者信息
- 1. 武汉大学人民医院药学部,湖北武汉430060
- 折叠
摘要
Abstract
Objective To study the preparation and in vitro drug release of in-situ temperature sensitive gel of insulin (IL-ISG) in order to study further in vivo. Methods IL-ISG was prepared using T-sensitive polymers poloxamer 407 and 188 as bases. The gel temperature of IL-ISG before and after diluted by artificial tears was determined. The base dissolution and IL release in vitro were studied by membraneless dissolution model. Results The gel temperature of IL-ISG before and after diluted by artificial tears was (30.4±0.2) t and (34.2±0.4) t, respectively. The base dissolution and IL release in vitro were both accorded with first-order models. Conclusion The IL-ISG has suitable gel temperature and significant sustained release property. It is valuable to study further.关键词
胰岛素/原位凝胶/凝胶溶蚀/体外释药Key words
insulin/ in-situ gel/ gel dissolution/ drug release in vitro分类
药学引用本文复制引用
王军..胰岛素眼用温度敏感即型凝胶的制备及其体外释药考察[J].广东药学院学报,2011,27(4):351-353,3.
