中华临床免疫和变态反应杂志2011，Vol.5Issue(3)：212-216,5.
韦格纳肉芽肿合并肺部感染的临床特征
Clinical Features of Patients with Wegener Granulomatosis Complicated with Pulmonary Infection
曾平 1张国华 2苟丽娟 2苏金梅 2李梦涛 2张文2
作者信息
- 1. 中国医学科学院北京协和医学院北京协和医院老年示范病房,北京,100730
- 2. 中国医学科学院北京协和医学院北京协和医院风湿免疫科,北京,100032
- 折叠
摘要
Abstract
Objective To investigate the clinical features of patient with Wegener granulomatosis ( WG) complicated with pulmonary infection. Methods Twenty three patients with WG complicated with pulmonary infection admitted to Peking Union Medical College Hospital in 12 years were retrospectively analyzed. Results Among 23 patients, 21.7% pulmonary infection occurred at the first diagnosis, and 52.2% occurred within 6 months, while 26. 1 % occurred more than 6 months. 73. 9% were generalized, and 26.1% were localized, accompanied with erythrocyte sedimentation rate ( ESR, 63.6%), C-reactionprotein ( CRP, 65%) increased, and immunoglobulin (30%) decreased. Antineutrophil cytoplasmic antibodies (ANCA) was positive in 82. 6%, and C-ANCA was positive in 69. 6% . The clinical manifestations of pulmonary infection were productive cough ( 86.9%), fever and fatigue(52. 2% ), hemoptysis (52. 2% ) , chest pain and pactoralgia (34. 8% ). The causative pathogen mainly were bacteria (56.5%), tubercle bacillus (43.5%), and fungas (39.1%). Diabetes mellitus or impaired glucose tolerance (34.8%) and hypoproteinemia (65.2%) were the common complication. Most patients (95.7%) were treated with corticosteroid and cyclophosphamide, 21.7% receive methyllprednisolone pulse therapy. Three patients died. Conclusions Patients with WG tend to complicate with pulmonary infection in the first six months, most of whom were generalized. The clinical manifestations were productive cough. The causative pathogens mainly were bacteria, tubercle bacillus, and fungas. Most patients were treated with corticosteroid and cyclophosphamide.关键词
韦格纳肉芽肿/感染/肺病Key words
Weeener eranulomatosis/ infection/ lung disease分类
医药卫生引用本文复制引用
曾平,张国华,苟丽娟,苏金梅,李梦涛,张文..韦格纳肉芽肿合并肺部感染的临床特征[J].中华临床免疫和变态反应杂志,2011,5(3):212-216,5.
