中国当代儿科杂志2011，Vol.13Issue(10)：771-775,5.
早产儿脑病的研究现状
Progress in encephalopathy of prematurity
摘要
Abstract
The preterm birth has been increasing for the last decade. With the development of neonatal intensive care techniques, the survival rate of preterm infants is increased markedly. However, the brain of preterm infants is so vulnerable to injury that preterm brain injury has become an enormous public health problem. Hypoxia-ischemia and infection/inflammation are two main perinatal risk factors causing premyelinating oligodendrocyte and cortical neuron injury. Encephalopathy of prematurity is characterized by diffuse white matter injury and neuronal/axonal disruption, leading to neurological disabilities such as cognitive impairment and cerebral palsy. The advancement in imaging techniques, especially magnetic resonance imaging, provides more information for preterm brain injury and brain development, which contributes to the diagnosis and follow-up of the preterm infants. This article reviews the progress in encephalopathy of prematurity in order to open a new window to prophylaxis and management of this disease.关键词
脑病/神经元/少突胶质前体细胞/早产儿Key words
Encephalopathy/Neuron/Premyelinating oligodendrocyte/Preterm infant分类
医药卫生引用本文复制引用
黄志恒,孙轶,陈超..早产儿脑病的研究现状[J].中国当代儿科杂志,2011,13(10):771-775,5.基金项目
国家自然科学基金资助项目(81070520,81100450). （81070520,81100450）
