中国当代儿科杂志2011，Vol.13Issue(10)：787-789,3.
C-kit和Cx43在新生儿自发性胃穿孔中的表达
Expression of c-kit and Cx43 in neonates with spontaneous gastric perforation
夏丽娜 1王志强 2王宗敏 1张普1
作者信息
- 1. 温州医学院附属育英儿童医院病理科,浙江,温州,325000
- 2. 池州市人民医院病理科,安徽,池州,247000
- 折叠
摘要
Abstract
Objective To study the clinical significance of interstitial cell of Cajal (ICC) in spontaneous neonatal gastric perforation by examining the expression of c-kit and Cx43 in neonates with this disorder. Methods The gastric specimens of 19 cases of neonatal gastric perforation from 2001 to 2010 and 8 cases of accidental death without digestive tract malformations ( control) were collected. Immunohistochemical staining was employed to examine the expression of c-kit and Cx43 (immunomarkers of ICCs) in gastric tissues. Results The muscular layer of the stomach wall became thinner or deficient in the gastric perforation group. C-kit and Cx43 positive cells in gastric tissues decreased significantly in the gastric perforation group compared with those in the control group ( P < 0. 01 ) . Conclusions The development of spontaneous neonatal gastric perforation is associated with the decreased quantity of ICCs and damaged gap junction structure of the stomach wall.关键词
自发性胃穿孔/Cajal间质细胞/C-kit/缝隙连接蛋白43/新生儿Key words
Spontaneous gastric perforation/Interstitial cell of Cajal/C-kit/Cx43/Neonate分类
医药卫生引用本文复制引用
夏丽娜,王志强,王宗敏,张普..C-kit和Cx43在新生儿自发性胃穿孔中的表达[J].中国当代儿科杂志,2011,13(10):787-789,3.
