摘要
Abstract
Objective To find the best schedule for tinea pedis treatment. Methods A total of 250 patients with tinea pedis were divided into five groups; group A (oral terbinafine combined with 1% topical bifonazole cream for 1 week), group B (oral ter-binafine for 1 week combined with 1% topical bifonazole cream for 2 weeks) , group C (oral terbinafine for 2 weeks combined with 1% topical bifonazole cream for 1 week), group D (oral terbinafine combined with 1% topical bifonazole cream for 2 weeks) , and group E(only 1 % topical bifonazole cream for 4 weeks). Efficacy and relapse rates were analysed at the end point, week 4, 24, 40, 56 and week 72. Results By the end of week 24, 40, 56 and week 72, clinical effective rate in group A, B, C and D showed statistical difference with that in group E, while group D showed statistical difference with group A and B by the end of week 40, 56 and week 72. At week 24, 40, 56 and week 72, microbiological cure rate in group A, B, C and D showed statistical difference with that in group E, while group D showed statistical difference with group A and B at week 56 and 72. At week 40, relapse rates in group A, B, C and D were statistically different from that in group E, while at week 56 and 72, group D showed statistical difference with group A and B. Conclusions Two-week treatment with oral terbinafine and 1% topical bifonazole cream has the best therapeutic effect and lowest relapse rate.关键词
足癣/特比萘芬/联苯苄唑乳膏/疗效/复发率Key words
tinea pedis/ terbinafine/ bifonazole cream/ treatment/ relapse rate分类
医药卫生
