中国实用妇科与产科杂志2011，Vol.27Issue(8)：595-598,4.
细胞外基质金属蛋白酶诱导因子、基质金属蛋白酶9及P38丝裂原活化蛋白激酶在子宫内膜异位症中的表达及相关性
摘要
Abstract
Objective To investigate the expression and association of the extracellular matrix metalloproteinase inducer (EMMPRIN) ,the matrix metalloproteinases-9( MMP-9) ,and the P38 mitogen-activated protein kinase( MAPK) in patients diagnosed with endometriosis (EMs ). Methods The expression of EMMPRIN, MMP-9, P38, p-P38 was detected by SABC immunohistochemistry in 44 patients with EMs (44 ectopic endometrium,38 eutopic endometrium) , and compared with 34 normal endometrium with non-endometriosis. Correlation analysis was done. Results The positive expression rates of EMMPRIN, MMP-9, P38 and p-P38 in the ectopic endometrium with EMs were significantly higher than the eutopic endometrium group and the control group ( P <0.05). Spearman correlation analysis showed that positive correlation was found in EMMPRIN, MMP-9, P38 and p-P38 in the ectopic endometrium group(P<0.05).The expression level of EMMPRIN, MMP-9 ,P38 and p-P38 in the stages of III - IV displayed significantly higher than those in I ~ II in the ectopic endometrium group ( P <0.05). The positive expression rates were no significant difference between the eutopic endometrium group and the control group(P > 0.05 ). Conclusion The expression of EMMPRIN, MMP-9 in the ectopic endometrium with EMs was significantly higher and positive correlation,and they may play an important role in implantation and development. P38 MAPK may have a pathophysiological role in EMs.关键词
子宫内膜异位症/细胞外基质金属蛋白酶诱导因子/基质金属蛋白酶9/P38丝裂原活化蛋白激酶/免疫组织化学Key words
endometriosis/ EMMPRIN/ MMP-9/ P38 MAPK/ immunohistochemistry分类
医药卫生引用本文复制引用
张婧,唐良萏,周敏,龙行涛..细胞外基质金属蛋白酶诱导因子、基质金属蛋白酶9及P38丝裂原活化蛋白激酶在子宫内膜异位症中的表达及相关性[J].中国实用妇科与产科杂志,2011,27(8):595-598,4.基金项目
国家自然科学基金资助(基金编号:30772034) （基金编号:30772034）
重庆市科委计划项目(编号:2007BB5316) （编号:2007BB5316）
