癌症（英文版）2011，Vol.30Issue(9)：585-589,5.DOI:10.5732/cjc.011.10314
Serglycin in human cancers
Serglycin in human cancers
摘要
Abstract
Serglycin belongs to a family of small proteoglycans with Ser-Gly dipeptide repeats,and it is modified with different types of glycosaminoglycan side chains.Intracellular serglycin affects the retention and secretion of proteases,chemokines,or other cytokines by physically binding to these factors in secretory granules.Extracellular serglycin has been found to be released by several types of human cancer cells,and it is able to promote the metastasis of nasopharyngeal carcinoma cells.Serglycin can bind to CD44,which is another glycoprotein located in cellular membrane.Serglycin's function of promoting cancer cell metastasis depends on glycosylation of its core protein,which can be achieved by autocrine as well as paracrine secretion mechanisms.Further investigations are warranted to elucidate serglycin signaling mechanisms with the goal of targeting them to prevent cancer cell metastasis.关键词
Serglycin/ cancer/ metastasis/ proteoglycanKey words
Serglycin/ cancer/ metastasis/ proteoglycan引用本文复制引用
Xin-Jian Li,Chao-Nan Qian..Serglycin in human cancers[J].癌症（英文版）,2011,30(9):585-589,5.基金项目
a grant from the StateKey Program of National Natural Science Foundation of China (No.81030043). （No.81030043）
