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A single nucleotide polymorphism in the matrix metalloproteinase 2 promoter is closely associated with high risk of nasopharyngeal carcinoma in Cantonese from southern China

Jian-Yong Shao Yun Cao Xiao-Ping Miao Ma-Yan Huang Ling Deng Jian-Jun Hao Xiao-Man Liang

癌症（英文版）2011，Vol.30Issue(9)：620-626,7.
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癌症（英文版）2011，Vol.30Issue(9)：620-626,7.DOI:10.5732/cjc.010.10592

A single nucleotide polymorphism in the matrix metalloproteinase 2 promoter is closely associated with high risk of nasopharyngeal carcinoma in Cantonese from southern China

A single nucleotide polymorphism in the matrix metalloproteinase 2 promoter is closely associated with high risk of nasopharyngeal carcinoma in Cantonese from southern China

Jian-Yong Shao 1Yun Cao 2Xiao-Ping Miao 3Ma-Yan Huang 4Ling Deng 1Jian-Jun Hao 2Xiao-Man Liang5

作者信息

  • 1. State Key Laboratory of Oncology in South China,Guangzhou, Guangdong 510060, P. R. China
  • 2. Department of Pathology,Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060,P. R. China
  • 3. Microbiology and Tumor Biology Center, Karolinska Institute,Stockholm S17177, Sweden
  • 4. Department of Experiment Research, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China
  • 5. Department of Epidemiology and Biostatistics, School of Public Health, TongjiMedical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P. R. China4Huangpu Chinese Traditional Medicine Hospital, Guangzhou, Guangdong 510360, P. R.China
  • 折叠

摘要

Abstract

Matrix metalloproteinase 2 (MMP2) has been shown to play an important role in several steps of cancer development.The-1306C/T polymorphism of the MMP2 gene displays a strikingly lower promoter activity than the T allele,and the CC genotype in the MMP2 promoter has been reported to associate with the development of several cancers.To assess the contribution of the MMP2-1306c/r polymorphism to the risk of nasopharyngeal carcinoma (NPC),we conducted a case-control study and analyzed MMP2 genotypes in 370 patients with NPC and 390 frequency-matched controls using real-time PCR-based TaqMan allele analysis.We found that subjects with the CC genotype had an increased risk (OR = 1.55,95% Cl = 1.05-2.27) of developing NPC compared to those with the CT or TT genotypes.Furthermore,we found that the risk of NPC was markedly increased in subjects who were smokers (OR = 15.04,95% Cl = 6.65-33.99),heavy smokers who smoked ≥20 pack-years (OR = 18.66,95% Cl = 7.67-45.38),or young (＜60 years) at diagnosis (OR = 1.52,95% Cl = 1.01-2.29).Our results provide molecular epidemiological evidence that the MMP2-1306c/r promoter polymorphism is associated with NPC risk,and this association is especially noteworthy in heavy smokers.

关键词

Matrix metalloproteinase 2 gene/ polymorphism/ nasopharyngeal carcinoma/ smoker/ epidemiology

Key words

Matrix metalloproteinase 2 gene/ polymorphism/ nasopharyngeal carcinoma/ smoker/ epidemiology

引用本文复制引用

Jian-Yong Shao,Yun Cao,Xiao-Ping Miao,Ma-Yan Huang,Ling Deng,Jian-Jun Hao,Xiao-Man Liang..A single nucleotide polymorphism in the matrix metalloproteinase 2 promoter is closely associated with high risk of nasopharyngeal carcinoma in Cantonese from southern China[J].癌症（英文版）,2011,30(9):620-626,7.

基金项目

Chinese State Key Basic Research Project (No.2011CB504805),National High Technology Research and Development Program of China (863 Program) (No.20060102A4002),and a grant of 985 Project from Ministry of Education of P.R.China. （No.2011CB504805）

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