中国临床药理学与治疗学2011，Vol.16Issue(8)：890-894,5.
蛇葡萄素钠协同卡铂抑制人肺腺癌SPC-A-1细胞增殖
Cytotoxic effect of ampelopsin sodium combined with carboplatin on human lung adenocarcinoma cell line SPC-A-1
徐明丽 1韩伟 2吴勇杰3
作者信息
- 1. 兰州大学基础医学院药理学研究所,甘肃省新药临床前研究重点实验室,兰州730000,甘肃
- 2. 甘肃省卫生学校,兰州730000,甘肃
- 3. 甘肃省定西市卫生学校,定西7430000,甘肃
- 折叠
摘要
Abstract
AIM: To investigate the cytotoxic effect and mechanism of ampelopsin sodium (AMP-Na) on human lung adenocarcionma cell line SPC-A-1 by alone or combined with carbopl-atin. METHODS: The inhibitory effects on proliferation of human lung cancer cell line SPC-A-1 were examined by MTT colorimetric assay. Flow cytometry (FCM) was employed to analyze the cell apoptosis. RESULTS Experimental study on cytotoxicity in vitro showed that AMP-Na decreased the survival rate of SPC-A-1 cells in a concentration-dependent manner. There was a synergistic cytotoxic effect on SPC-A-1 cells treated with AMP-Na combined with carbopla-tin. The apoptosis rate in group treated withAMP-Na combined with carboplatin was significantly increased as compared with that in group treated with carboplatin alone. CONCLUSION-AMP-Na decreases SPC-A-1 cells survival rate in a concentration dependent manner, and shows significant cytotoxic activity. There is a synergistic cytotoxic effect on SPC-A-1 cells treated with AMP-Na combined with carboplatin. The mechanism of AMP-Na is probably that it can induce SPC-A-1 cells apoptosis.关键词
蛇葡萄素钠/卡铂/人肺腺癌SPC-A-1细胞/细胞凋亡Key words
Ampelopsin sodium/ Carboplatin/ Human lung adenocarcionma cell line SPC-A-1/ Apoptosis分类
医药卫生引用本文复制引用
徐明丽,韩伟,吴勇杰..蛇葡萄素钠协同卡铂抑制人肺腺癌SPC-A-1细胞增殖[J].中国临床药理学与治疗学,2011,16(8):890-894,5.
