中国临床药理学与治疗学2011，Vol.16Issue(8)：929-932,4.
艾司西酞普兰联合小剂量阿立哌唑治疗伴躯体症状抑郁症的研究
Study on the escitalopram combined with low dose of aripiprazole in the treatment of depression with somatic symptoms
夏金校 1姚华华 1王一冰 1曹世林 1甘建光 1段迪 1吕柏军1
作者信息
- 1. 绍兴市第七人民医院精神科,绍兴312000,浙江
- 折叠
摘要
Abstract
AIM: To explore the clinical efficacy of escitalopram combined with low dose of aripiprazole in the treatment of depression with somatic symptoms. METHODS: Eighty patients suffering from depression with somatic symptoms were randomly divided into study group (n = 41) and control group (n = 39), who received either escitalopram combined with low dose of aripiprazole or escitalopram only, respectively. The clinical efficacy and safety were evaluated with Hamilton Depression Rating Scale (HAMD), Self-rating Depression Scale (SDS), Clinical Global Impression (CGD , Treatment E-mergent Symptom Scale (TESS) and Dysfunctional Attitudes Scales (DAS) at the point of baseline and the 1st, 2nd, 4th and 8th weekend. Meanwhile, the medication compliance andsymptom recrudescence rate of two groups were also assessed in 3 months. RESULTS: Scores of HAMD, SDS and CGI decreased in both groups, but more significantly and quickly in study group. There was no difference between two groups in TESS. Patients in study group had better compliance, fewer symptom recrudescence rate and lower scores in DAS in 3 months, compared with control group. CONCLUSION: Escitalopram combined with low dose of aripiprazole works better in the treatment of depression with somatic symptoms than using escitalopram only.关键词
艾司西酞普兰/阿立哌唑/躯体症状/抑郁症Key words
Escitalopram/ Aripiprazole/ Somatic symptoms/ Depression分类
医药卫生引用本文复制引用
夏金校,姚华华,王一冰,曹世林,甘建光,段迪,吕柏军..艾司西酞普兰联合小剂量阿立哌唑治疗伴躯体症状抑郁症的研究[J].中国临床药理学与治疗学,2011,16(8):929-932,4.
