中国普通外科杂志2011，Vol.20Issue(8)：839-843,5.
可吸收性多聚糖止血海绵对创伤愈合的影响
Effect of absorbable hemostatic polysaccharide sponge on wound healing
王青 1鲁建国 1杨涛 1董瑞 1杨媛 1杨小军1
作者信息
- 1. 第四军医大学唐都医院普通外科,陕西西安710038
- 折叠
摘要
Abstract
Objective To investigate the effect of absorbable hemostatic polysaccharide sponge on wound healing. Methods The open-wound animal models were established in Guangxi Bama minipigs. The porcine models were then randomized into group A ( absorbable hemostatic polysaccharide sponge treatment group) , group B ( absorbable gelatin sponge treatment group ) and group C ( no treatment group). Wound healing responses were monitored at 1,3, 5, 7,14, 21 and 28 d after injury. The histopathological features and transforming growth factor-β 1 ( TGF-β1 ) expression of the tissue from wound edge at each time point of each group were examined using HE and immunohistochemical staining and compared, respectively. Furthermore, the infrastructure of the wound tissues at 7 d after injury was observed by transmission electron microscapy ( TEM ) . Results The wound healing rate of group A was significantly higher than that of group B and C at the time points from 5 to 28 d after injury ( P < 0. 05 ) . The positive expression rate of TGF-β1 in the specimens of group A was significantly higher than that of group B and C, especially at 7 d after injury ( P < 0. 05 ). The results of TEM demonstrated that the fibroblasts in wound tissues of group A were mainly synthetic and secretory type, while they were mainly proliferative type in wound tissues of group B and C. Conclusions Absorbable hemostatic polysaccharide sponge has accelerating effect on wound repair.关键词
伤口愈合/药物作用/可吸收性多聚糖止血海绵/转化生长因子-β1Key words
Wound Healing/drug eff/Absorbable Hemostatic Polysaccharide Sponge/TGF-β1分类
医药卫生引用本文复制引用
王青,鲁建国,杨涛,董瑞,杨媛,杨小军..可吸收性多聚糖止血海绵对创伤愈合的影响[J].中国普通外科杂志,2011,20(8):839-843,5.
