中国临床药理学与治疗学2011，Vol.16Issue(8)：867-873,7.
MC-002对大鼠局灶性脑缺血/再灌注治疗时间窗的研究
Therapeutic time window of MC-002 on focal cerebral ischemia-reperfusion rats
摘要
Abstract
AIM: To investigate therapeutic time window of MC-002 on the focal cerebral is-chemia-reperfusion rats. METHODS; The models with cerebral ischemicre-reperfusion were induced by intraluminal middle cerebral artery occlusion (MCAO) with a nylon monofilament suture, 2 h occlusion followed by 22 h reperfu-sion. Therapeutic medicine was intravenously administered after reperfusion for 0, 0.5, 1, 2, 4 h. The effect of MC-002 at different doses on neurological scores, infarct sizes, water contents, pathological changes and the biochemical indexes of CIRI rats were examined. RESULTS; MC-002 administered at 0, 0.5, 1, 2 h after reperfusion significantly improved the CIRI rats'neurological function and reduced the cerebral infarct size and edema; The content of MDA and LD in brain were markedly decreased (P<0. 05 and P<0. 01), and the activity of SOD was significantly enhanced (P<0. 01). The pathological observations showed that neuronal cells shape and number were obviously improved after treated with MC-002 compared with model . Groups. CONCLUSION; The results showed that the therapeutic time window of MC-002 extended for up to 2 h after CIRI.关键词
MC-002/局灶性脑缺血/再灌注/治疗时间窗Key words
MC-002/ Focal cerebral ischemi- areperfusion/ Therapeutic time window分类
医药卫生引用本文复制引用
曾胜男,何广卫,吴强,袁晓艳,吴玉林..MC-002对大鼠局灶性脑缺血/再灌注治疗时间窗的研究[J].中国临床药理学与治疗学,2011,16(8):867-873,7.基金项目
十一·五重大专项课题号(2009ZX09103-123) （2009ZX09103-123）
