摘要
Abstract
Objective To investigate the relationship of the infection of subtype or co-infection of multi-subtype of human papillomavirus (HPV) with cervical intraepithelial neoplasia( CIN). Metheds From november,2007 to april,2008 in the general hospital of Tianjin medical university, the detection of HPV subtype were tested by polymerase chain reaction ( PCR),DNA gene chip probe hybridization. All the cases was divided into two groups accroding to their age, lower or e-qual to 35 years is divided into group A,older than 35 years is divided into group B. Results The incidence of HPV infection in total 98 cases is 72.41% (21/29) of CIN I ,75% (27/36) of CIN II ,96. 97% (32/33) of CINI. Sigle HPV subtype infection in CIN I ,CIN II and CIN III is 41. 38% ( 12/29) ,44. 44% (16/36) and 57. 58% ( 19/33) respectively ; double HPV subtype infection in CIN I , CIN II and CIN HI is 27. 59% (8/29 ) , 19. 44% ( 7/36) and 27. 27% (9/33 ) respectively; multiple HPV subtype infection in CIN I , CIN II and CIN I is 3.45% (1/29), 11. 11% (4/36) and 12.12% (4/33) respectively. The main subtype infected in CIN I was lower risk HPV( LR-HPV), while in CIN I , HPV16 being the dominant. The incidence of HPV16 infection in group A and B is 20.93% ( 9/43), 40% (22/55) respectively ; and the difference is significant (P < 0. 05). Conclusion The incidence of HPV infection rise with the progress of the grade of CIN.companied by rising trence of double or multiple HPV infection. The subtype of HPV infected in CIN DI is different with the progress of the disease. The main subtypes of HPV infected in CIN II is HPV 16 and HPV58. The double or multiple HPV infection may promote the progress of CIN. It will greatly reduce the incidence of CIN HI or inversive cervical cancer to prevent or curb the infection of HPV16 and HPV58.关键词
宫颈上皮内瘤变/人乳头瘤病毒/宫颈肿瘤Key words
cervical intraepithelial neoplasia/human papillomavirus/cervical tumor分类
医药卫生
