四川大学学报（医学版）2011，Vol.42Issue(5)：630-632,3.
TAO眼眶成纤维细胞上CCR1的表达
Expression of CCR1 in the Orbital Fibroblasts with Thyroid Associated Ophthalmopathy
摘要
Abstract
Objective To investigate the expression of chemokine receptor (CCR1) in the orbital fibroblasts (Ofs) with thyroid associated ophthalmopathy (TAO) and to explore the pathogenesis of TAO. Methods By immunohistochemistry, the expression of CCR1 was studied in 25 cases of TAO patientsand 10 normal control subjects and the correlation between CCR1 and GAS was analysed. Results The expression of CCR1 in the Ofs with TAO was positive, but it was negative or weak positive in normal control subjects. The difference between them was significant (P<0. 05). And the expression of CCR1 in the Ofs with TAO had no significant correlation with GAS (r=0. 048,P>0. 05). Conclusion The expression of chemokine receptor CCR1 is higher on Ofs of TAO patients than that of normal subjects. CCR1 maybe play a role in pathogenesis of TAO.关键词
CCR1/甲状腺相关眼病/发病机制/成纤维细胞/免疫组化Key words
CCR1/Thyroid associated ophthalmopathy/Pathogenesis/Fibroblasts/ Immunohistochemistry引用本文复制引用
刘春玲,张学进,郭波,杨俊峰,罗清礼..TAO眼眶成纤维细胞上CCR1的表达[J].四川大学学报（医学版）,2011,42(5):630-632,3.基金项目
国家自然科学基金(批准号30371518)和四川省科技厅科技支撑项目(项目编号2009JY0007-1)资助 （批准号30371518）
