中国实用内科杂志2011，Vol.31Issue(9)：687-689,3.
FABC预处理异基因造血干细胞移植治疗难治未缓解急性白血病临床研究
Successful treatment of refractory,unremitting acute leukemia by allogeneic hematopoietic stem cell transplantation with FABC conditioning regimen.
摘要
Abstract
Objective To explore the efficacy and safety of allogeneic hematopoietic stem cell transplantation ( allo-HSCT) with FABC conditioning regimen for treatment of refractory unremitting acute leukemia patients. Methods Eighteen patients with refractory unremitting acute leukemia underwent allo-HSCT with FABC conditioning regimen. Hemopoietic recovery,engraftment,acute/chronic graft versus host disease (GVHD) ,transplantation-related mortality ( TRM), relapse, overall survival ( OS ) and disease free survival ( DFS) post-HSCT were analyzed. Results All of these patients attained fully donor engraftment between days 14 and 21 post transplantation. The median time to ANC > 0. 5 x 109/L and PLT > 20 x 109/L was 12(range 7-72) and 13(range 7 ~ 60) days after transplantation, respectively. The cumulative incidence of acute and chronic GVHD was 50% (9/18) and 73. 3% (11/15) Respectively. During follow-up for a mean of 10. 5( range 3. 1 -66. 6) months post transplantation, the TRM was 5. 6% (1/18) and the relapse rate was 38. 6% (7/18). The one-year overall survival (OS) probability and disease-free survival (DFS) was (58.9±13.2)% and (53. 6 ± 15. 5)% .respectively. Multivariate analyses by the stepwise Cox regression, chronic GVHD was shown to be an independent factor favoring DFS. Conclusion Allo-HSCT by FABC conditioning regimen is a safe and effective option for refractory unremitting acute leukemia patients.关键词
难治性未缓解急性白血病/异基因造血干细胞移植/移植物抗宿主病Key words
refractory incomplete remission acute leukemia/ allogeneic hematopoietic stem cell transplants-tion/ graft versus host disease分类
医药卫生引用本文复制引用
翁建宇,林伟,黄梓伦,刘晓力,杜欣,罗成伟,邹小立,凌伟,吴穗晶,郭荣,邓程新,陆泽生..FABC预处理异基因造血干细胞移植治疗难治未缓解急性白血病临床研究[J].中国实用内科杂志,2011,31(9):687-689,3.基金项目
国家自然科学基金项目(30972790,81070445) （30972790,81070445）
广东省自然科学基金项目(10151008004000024) （10151008004000024）
广东省科技计划项目(2009 A030200009) （2009 A030200009）
