四川大学学报（医学版）2011，Vol.42Issue(5)：657-660,4.
溴新斯的明缓释片的药动学及相对生物利用度
Pharmacokinetics and Relative Bioavailability of Neostigmine Bromide Sustained-release Tablets
摘要
Abstract
Objective To study the pharmacokinetics and relative bioavailability of neostigmine bromide conventional tablets and sustained-release tablets in rabbits. Methods Six healthy rabbits were randomly divided into two groups for a cross self-contrast trial. RP-HPLC was used to detect plasma concentrations of neostigmine bromide. The pharmacokinetic parameters were calculated with the aid of DAS 2. 0 software. Results The main pharmacokinetics parameters of the sustained-release tablets and conventional tablets were as follows, respectively; Tmax(3. 67±1.51) h and (1. 58±0.38) h; Cmax(5. 04±l. 19) mg/L and (4. 56±1.70) mg/L; AUC(0-∞)(32. 82± 9. 88) mg/L×h and (29. 84± 14. 27) mg/L×h. The relative bioavailability of the neostigmine bromide sustained-release tablets was 115. 4%. Conclusion The pharmacokinetics of neostigmine bromide accords with two compartments model, showing constant plasma concentration and relatively high bioavailability.关键词
溴新斯的明/高效液相色谱法/药动学/相对生物利用度Key words
Neostigmine bromide/HPLC/Pharmacokinetics/Relative bioavailability引用本文复制引用
熊华蓉,谭群友,刘碧林,罗文,张景勍..溴新斯的明缓释片的药动学及相对生物利用度[J].四川大学学报（医学版）,2011,42(5):657-660,4.基金项目
教育部博士点基金(20095503120008)和重庆市教育委员会(首批高等学校优秀人才资助,KJ090308)资助 （20095503120008）
