成都中医药大学学报2011，Vol.34Issue(2)：30-34,5.
清肾颗粒对慢性肾衰竭湿热证患者血清超敏C反应蛋白及同型半胱氨酸的干预作用
Curative Clinical Efficacy of Qing-shen Granule to Changes of Blood High-sensitivity C-reactive Protein and Hemocysteine in Damp-heat Syndrome of Chronic Renal Failure Patients
摘要
Abstract
Objectives; To observe the changes of serum creatinine (Scr), blood plasm high-sensitivity c-reactive protein (hs-CRP) and hemocysteine (Hcy) in sharp deterioration damp-heat syndrome (DHS) of chronic renal failure (CRF) and the curative efficacy of Qingshen granule (QSG, 清肾颗粒). . Methods; Sixty cases of DHS of CRF were randomly divided into treatment group (n=30) and control group (n=30) , normal control group (n=20) was set up too. The treatment group and control group were treated with conventionally therapeutic methods of western medicine and Traditional Chinese Medicine (TCM) for four weeks. Beside these QSG was added into treatment group and no other medicine which can affect the renal function was applied in the two groups.The levels of blood plasm hs-CRP, Hcy, Scr and the score of TCM were observed in sixty cases before and after therapy. Results: The total effective rate of clinical effect in the treatment group was 90% , which was better than that in the control group 60% , the difference was significant (P ＜ 0. 05) . The total effective rate of syndrome of Traditional Chinese Medicine in the treatment group was 90% , and obviously higher than the control group's 63. 33% , the difference was particularly significant (P ＜0. 01) . The levels of blood plasm hs-CRP and Hcy in DHS of CRF were obviously higher as compared to the normal control group (P ＜0. 01) , and these indexes were no significant diversity between the treatment group and the control group (P ＞ 0. 05) . After therapy with QSG the levels of blood plasm hs-CRP and Hcy were markedly decreased (P ＜ 0. 01) in the treatment group, but the changes in control group are not so much (P ＜0. 05 ) , there is significant diversity in the two groups (P＜0. 05) . Conclusions; The cases with sharp deterioration DHS of CRF exist the state of high blood plasm hs-CRP and Hcy. QSD could reduce the levels of blood plasm hs- CRP and Hcy, improve renal function, ease clinical symptoms, its mechanism might be related with the lowering of blood plasm hs-CRP and Hcy.关键词
慢性肾衰竭/急剧加重/湿热证/超敏-C反应蛋白/同型半胱氨酸/清肾颗粒Key words
Chronic renal failure/ sharp deterioration/ damp-heat syndrome/ hs-CRP/ Hcy/ Qingshen granule分类
医药卫生引用本文复制引用
刘家生,王亿平,茅燕萍,刘玲,方琦..清肾颗粒对慢性肾衰竭湿热证患者血清超敏C反应蛋白及同型半胱氨酸的干预作用[J].成都中医药大学学报,2011,34(2):30-34,5.基金项目
安徽中医学院临床科学基金项目(编号:2008lcky019) （编号:2008lcky019）
