成都中医药大学学报2011，Vol.34Issue(2)：49-51,3.
芪丹化痰汤对急性心肌缺血大鼠损伤保护作用研究
Protective Efect of Qi-dan-hua-tan Decoction on Acute Myocardial Ischemia Injury of Rat
摘要
Abstract
Objective: To observate the protection of the Qidanhuatan Decoction on acute myocardial ischemia injury. Methods : 60 Wistar rats were divided randomly into the blank group, the model group, the Qidanhuatantang with low dose group., the Qi-danhuatantang with normal dose group and the Qidanhuatantang with high dose group, enalapril maleatet group, 10 rats per group. The blank group and the model group were given saline water, while all treatment groups were given medicines, continuing 7 days. After 7 day for perfuse drug, except the blank group, the others groups were given hypophysin (0. 6U/kg) intraperitoneal injection for modeling. The expression level of Serum CK, LDK were measured after 1 hours through draw blood from abdominal aorta. Results : Comparison with blank group, the level of serum level of CK, LDK in model group was obviously higher (P ＜ 0. 05) ; comparison with model group, all treatment groups decreased serum activity and content of CK, LDK (P＜0. 05), there was no significantly difference between treatment groups. Conclusion; The Qidanhuatan Decoction could decreas the serum activity and content of CK, LDK of acute myocardial ischemia, which could effectively protectischemic myocardium.关键词
心肌缺血/芪丹化痰汤/血清肌酸激酶/乳酸脱氢酶Key words
Myocardial ischemia/ qidanhuatan cecoction/ creatine kinase/ lactate dehydrogenase分类
医药卫生引用本文复制引用
姜岑,谢磊,王卫星,黄秀深,贾波..芪丹化痰汤对急性心肌缺血大鼠损伤保护作用研究[J].成都中医药大学学报,2011,34(2):49-51,3.基金项目
成都中医药大学科技发展基金项目(编号:ZRYB200926) （编号:ZRYB200926）
